NIBAN1 and nonpapillary renal cell carcinoma: FAM129A knockdown and miR-4521 overexpression reduced the proliferations and increased the apoptosis of 786-O and ACHN (Figs. 5 and 6), suggesting that FAM129A overexpression with miR-4521 deficiency might enhance ccRCC progression by promoting cancer cell growth by reducing apoptosis.