P4HB and hypertriglyceridemia: Thus, taking into account our previous reports that hypertriglyceridemia in MSG-obese rats is associated with activation of the XBP-1s/PDI/MTP axis [8] and that HESc reverted their characteristic NAFLD and hypertriglyceridemia [23], in the present study, we sought to investigate the molecular mechanisms underlying the antihypertriglyceridemic activity of HESc in MSG-obese rats.