In this study, we aimed to provide an updated and comprehensive view on the optimum neoadjuvant regimens for patients with HER2-positive breast cancer, through a random-effect network meta-analysis of all relevant randomized evidence comparing the relative efficacy and tolerability of the commonly used neoadjuvant regimens including CTP, MP, CT, CP, TP, CTL, CL, and chemotherapy alone. The gene discussed is ERBB2; the disease is breast carcinoma.