ERBB2 and breast carcinoma: To date, four HER2-targeted agents, monoclonal antibody trastuzumab, small-molecule inhibitor lapatinib, anti-HER2 heterodimerization domain antibody pertuzumab, and antibody-drug conjugate trastuzumab emtansine, have been approved for use in patients with metastatic HER2-positive breast cancer, and trials have been conducted, or ongoing, in both adjuvant and neoadjuvant settings.