ERBB2 and breast cancer: In this study, we aimed to provide an updated and comprehensive view on the optimum neoadjuvant regimens for patients with HER2-positive breast cancer, through a random-effect network meta-analysis of all relevant randomized evidence comparing the relative efficacy and tolerability of the commonly used neoadjuvant regimens including CTP, MP, CT, CP, TP, CTL, CL, and chemotherapy alone.