The present network meta-analysis of 16 randomized controlled trials of 3,868 patients with breast cancer defined optimal neoadjuvant regimens for HER2-positive breast cancer patients by comparison of the relative efficacy and safety profiles of 8 commonly used neoadjuvant regimens, i.e., CTP, MP, CT, CP, TP, CTL, CL, and chemotherapy alone. This evidence concerns the gene ERBB2 and breast carcinoma.