Our results showed that USP6NL mRNA and protein expression was significantly increased in tumorous colorectal tissue when compared with none-tumorous colorectal tissues (Fig. 1a, d), moreover, data from TCGA and GEO database showed that USP6NL mRNA was significantly increased in CRC patients when compared with corresponding healthy people (Fig. 1b, c), which suggested the participation of USP6NL in human CRC. Here, USP6NL is linked to colorectal carcinoma.