Emerging data on the mechanisms of reversing immuno-suppression in tumor microenvironment have led to the development of novel ICBT strategies in RCC patients, such as combination therapy of Nivolumab (anti-PD-1) plus Ipilimumab (anti-CTLA-4), or even ICBT in combination with targeted therapies [9, 14, 15]. The gene discussed is PDCD1; the disease is renal cell carcinoma.