Likewise, comparisons between overweight PCOS patients (N = 198) and lean PCOS patients (N = 246) showed that, except for levels of DHEA, ASD, prolactin, estradiol, insulin Ab, Apo-A1, and asprosin, levels of other metabolic parameters in overweight PCOS patients were significantly different from those of lean PCOS patients (Table 5; Fig. 1). This evidence concerns the gene INS and polycystic ovary syndrome.