Comparison of metabolic parameters between ATPIII(+) PCOS and ATPIII(−) PCOS patients showed that ATPIII(+) PCOS patients (N = 235) were characterized by higher levels of BMI, BAI, LBW, SBP, DBP, WC, HC, WC/HC ratio, F-M score, free testosterone, TSH, fasting and stimulated glucose, fasting and stimulated insulin, fasting and stimulated C-peptide, HOMA-IR, AUC(glucose), AUC(insulin), LDL cholesterol, triglyceride, irisin, and GIP when compared to ATPIII(−) PCOS patients (N = 209)(Table 4; Fig. 1). Here, FNDC5 is linked to polycystic ovary syndrome.