AGT and cardiac hypertrophy: As shown in Fig. 2A, interventricular septum diastolic dimension (IVS, d) and left ventricular posterior wall diastolic dimension (LVPW, d) of Ang II-induced mice were increased by 44.04% (0.764 ± 0.026 vs 1.100 ± 0.041) (Fig. 2B) and 37.60% (0.774 ± 0.024 vs 1.065 ± 0.042) (Fig. 2C) respectively, when compared with age-matched sham control mice, indicating cardiac hypertrophy was induced by Ang II infusion.