Out of 506 people with ESR ≥ 100, 69 (13.6%) developed cancer in 1 year; with CRP ≥ 100 (n = 1983), 135 (6.81%) developed cancer; with PV ≥ 2.0 mm/h (n = 342), 31 (9.06%) developed cancer. The gene discussed is CRP; the disease is cancer.