In a study conducted by Quellhorst, insulin requirement per day was determined in 16 HD, 18 haemofiltration, 26 continuous ambulatory peritoneal dialysis (CAPD) and 14 intermittent peritoneal dialysis (IPD) patients at the onset of diabetes, at the start of artificial kidney treatment and 18 months after the beginning of diabetes therapy. This evidence concerns the gene INS and diabetes mellitus.