MMP3 and chronic kidney disease: Our data also show a significant increase in MCP1 (p < 0.05), ICAM-1 (p < 0.001), VCAM-1 (p < 0.001) and MMP3 (p < 0.05) mRNA expression in the ipsilateral hemispheres of CKD mice compared to SHAM-operated mice (Supplementary Fig. 4).