One study showed that Aviscumine activated the MAP kinase pathway, p38, Erk1/2, and SAP/JNK in ovarian cancer SKOV3 cells; activated caspases and two MAP kinase pathways in keratinocytes in vitro; and inhibited protein synthesis by inactivating the 60 S subunit of ribosomes39. This evidence concerns the gene MAPK8 and ovarian cancer.