MYC and Burkitt lymphoma: To confirm that Fraxini’s anticancer activity was mediated by posttranslational regulation of c-Myc, especially via regulating c-Myc phosphorylation, we tested the antiproliferative effect of Fraxini in Burkitt lymphoma Raji cells, which harbor CMYC T58 mutation, resulting in c-Myc stabilization37.