Recent evidence revealed genetic alterations in the RTK/RAS/β-catenin and PI3K/AKT/PTEN pathways in endometrial tumor tissue2; however, it has also been reported that a significant subset (e.g. ~50%)3 of EC does not contain genetic mutations in PTEN, TP53, or CTNNB1, suggesting an etiology other than common genetic mutations. This evidence concerns the gene PTEN and endometrium neoplasm.