To evaluate the comparative impact of Stxbp1 deletion in excitatory and inhibitory neurons on absence seizures, we generated Stxbp1 conditional knockout mice using Emx1-Cre recombinase (Emx1-Cre)11,31,32-mediated dorsal-telencephalic (i.e., the cerebral cortex, hippocampus, and amygdala, but excluding the striatum, globus pallidus, and thalamus) excitatory neuron-specific deletion or Vgat-Cre11,32-mediated global inhibitory neuron-specific deletion. Here, SLC32A1 is linked to juvenile absence epilepsy.