Interestingly, we also found TRs important for the survival and proliferation of cancer cells under nutrient limitation or stress, such as the activating transcription factor 5 (ATF5)34 and the SNF2-related CPB activator protein (SRCAP), a direct regulator of phosphoenolpyruvate carboxykinase 2 (PCK2)35, a gluconeogenic enzyme essential to maintain cell proliferation under limited glucose conditions in cancer cells36. The gene discussed is ATF5; the disease is cancer.