Colocalization analysis with these phenotypes identified 7 loci (prioritized genes: FGF5, PRKAG2, TRIB1, DCDC5/MPPED2, L2HGDH/SOS2, UMOD, SALL1) having significantly colocalized association signals with hypertension, essential hypertension, and/or coronary atherosclerosis and 1 locus (prioritized gene: GCKR) that colocalized with association of type 2 diabetes (Supplementary Data 5). The gene discussed is SOS2; the disease is essential hypertension.