APP and Alzheimer disease: In light of our evidence that IF enhances GABAergic tone, we therefore designed a study to determine whether IF would counteract neuronal network hyperexcitability and modify deficits in learning and memory and synaptic plasticity in an mouse model (Supplementary Fig. 3a) in which human APP with three different familial AD mutations is knocked into the endogenous mouse APP locus, thereby precluding non-specific effects resulting from random genome insertion and gene overexpression25.