MAPK8 and melanoma: As shown in Fig. 4a, b and Supplementary Fig. 6a–d, treatment of BRAFWT melanoma cells with TNFα or IL-1β led to a rapid induction of p-MEK/p-ERK levels, which was accompanied with the activation of JNK, supporting the correlation between BRAF function and the JNK/ITCH pathway activation.