Moreover, in the TCGA cutaneous melanoma (TCGA-SKCM) RPPA (reverse-phase protein array) dataset containing 354 tumors, we found a positive correlation (r = 0.28, p = 5.4 × 10−8) between pT183/pY185-JNK1/2 and pT202/pY204-ERK1/2 signals from this cohort of samples (Supplementary Fig. 7b). This evidence concerns the gene MAPK8 and cutaneous melanoma.