Genetic analyses of myeloma over the last quarter century have revealed a bifurcation of founding genetic alterations with approximately half of myelomas containing an immunoglobulin heavy chain (IgH) translocation11, which most commonly juxtapose the IgH enhancer with CCND1 [t(11;14)], WHSC1 [t(4;14); also known as MMSET and NSD2], or MAF [t(14;16)]. The gene discussed is NSD2; the disease is plasma cell myeloma.