The density of several transcripts including Ccr6, Cd19, and Il12, and to a lesser degree Cd3e, Cxcr3, and Cd8b mRNA was increased in the lymphoid in relation to the epithelioid areas (Fig. 3d) after a supervised annotation of the lymphoid and the epithelioid areas of the granulomas based on H&E staining. The gene discussed is CD8B; the disease is Granuloma.