Interestingly, a strong TCF4 signal was observed around the H2A.Z promoter in HCT116 cells (Fig. 7a), which are derived from colorectal cancer, as Caco2 cells: a major TCF4 peak could be seen about 500 bp upstream from the H2A.Z transcription start site (TSS), whereas weaker binding was observed downstream from the TSS. The gene discussed is TCF4; the disease is colorectal cancer.