ATG16L1 and inflammatory bowel disease: The most common IBD-linked polymorphism in ATG16L1, the T300A allele, was shown to prevent binding of the WDD to proteins containing a novel WDD-binding amino acid motif22, and also to facilitate ATG16L1 processing by caspase 3 leading to defects in anti-bacterial autophagy and enhanced cytokine responses26,27.