EGFR and hepatocellular carcinoma: Treatment of TKO HCC cells with orthovanadate salt, a general phosphotyrosyl phosphatase inhibitor53, disrupted the interaction between β-catenin and the slow migrating form of E-cadherin and decreased the expression of β-catenin, E-cadherin, and EGFR (as illustrated by the difference of signal intensity in the input lanes) (Fig. 7f).