AXIN2 and hepatocellular carcinoma: To determine the consequence of β-catenin recruitment by the AJ complex for Wnt signaling in HCC, we used a set of established Wnt target genes (glul, tbx3, lgr5, and axin2) as a readout for Wnt signaling activity in the TCGA dataset of HCC patients and found that E-cadherin expression negatively correlates with Wnt signaling activity (Fig. 4g).