Ectopic expression of dnTCF4 in TKO HCC cells repressed the expression of axin2 (similar to β-catenin silencing) and GS/glul (albeit this could be through a β-catenin-independent mechanism43) (Fig. 3j, k), but failed to repress TKO HCC cell and organoid proliferation (Fig. 3l, m). Here, AXIN2 is linked to hepatocellular carcinoma.