EGFR and hepatocellular carcinoma: To determine the fate of EGFR upon disruption of its stabilizing interaction with the AJ complex, we treated TKO HCC cells with CHX for increasing amount of time and found that repression of β-catenin increased the degradation of EGFR, suggesting that EGFR is degraded and not recycled upon disruption of the AJ complex (Fig. 7h).