In addition, a positive correlation between METTL3 and p-AKT or p-p70S6K levels and a negative correlation between PHLPP2 and METTL3 or p-AKT or p-p70S6K levels were observed in non-tumor pancreatic tissues from smokers (Fig. 7h) and nonsmokers (Fig. 7i). Here, RPS6KB1 is linked to neoplasm.