We then sought to identify transcription factor(s) involved in METTL3 overexpression and found that based on the suggestion of in silico analysis (Supplementary Fig. 5a), only NFIC, among other four potential transcription factors, was significantly and positively correlated with METTL3 at the RNA level in both tumor and non-tumor pancreatic tissues, and this result was seen in TCGA and Genotype-Tissue Expression Project data (Supplementary Fig. 5b). This evidence concerns the gene METTL3 and neoplasm.