RPS6KB1 and neoplasm: We also detected METTL3, PHLPP2, p-AKT, and p-p70S6K protein levels in non-tumor pancreatic tissue samples from smokers and nonsmokers and found that all of them were significantly higher in smokers than in nonsmokers, except for PHLPP2 that was lower in smokers compared with nonsmokers (Fig. 7f, g).