MYC and B-cell chronic lymphocytic leukemia: Thus, to identify which TFs may carry the potential to rewire CLL cells and promote lineage plasticity in CLL, we further mined the regions marked by H3K27ac-H3K27me3 for transcription factor motif enrichment and identified a significant enrichment of the proto-oncogene MYC motif, a TF associated with lineage plasticity and CLL transformation to aggressive large B cell lymphoma33 (Hypergeometric test P < 0.0001; Fig. 4e).