A total of 297 super-enhancers were differentially regulated in CLL compared with normal B cells (absolute log2[H3K27ac fold-change] >2 and Wald test BH-FDR <0.01; see Methods), with increased H3K27ac in proximity to genes critical for lymphocyte proliferation and differentiation, including BCL2, LEF1, and CTLA415–17 (Fig. 1a–c; Supplementary Fig. 1d) and involved in pathways previously reported to play key roles in CLL (e.g., B cell receptor, NF-kB and MAPK inflammatory signaling pathways3; Fig. 1d). This evidence concerns the gene BCL2 and B-cell chronic lymphocytic leukemia.