We have preliminary evidence indicating that mouse p53 is ubiquitinated in C57BL/6 MEFs during MAV-1 infection, which suggests that the mouse p53 degradation seen in human cells could be paralleled by degradation of endogenous mouse p53 and mouse PKR in mouse cells, mediated by MAV-1 E4orf6 and E1B 55K during infection. Here, EIF2AK2 is linked to infection.