Importantly, silencing of RET inhibited the highly increased tumor growth and metastatic ability of lamin B1–depleted cells, evident by the significant decrease in the metastatic area, number of tumor nodules, and tumor volume of mice injected with lamin B1/RET KD compared with lamin B1 KD LLC1 cells (Fig. 5, A–D). This evidence concerns the gene LMNB1 and neoplasm.