Immunostainings using two different antibodies revealed lower expression of lamin B1 in SCLC and a progressive loss of lamin B1 in high-grade adenocarcinoma and SCC, which have a significantly worse prognosis compared with lower grade tumors (Fig. 1, A and C; and Fig. S1, A and B). The gene discussed is LMNB1; the disease is small cell lung carcinoma.