Thus, lamin B1 levels are significantly reduced in tumor cells of lung cancer patients but are high in immune cells, which have been shown to exhibit stage-dependent accumulation in human lung tumors (Banat et al., 2015) decrease of lamin B1 levels in lung cancer compared with nonmalignant lung cells/tissues was confirmed by Western blot analysis of mouse lung epithelial (MLE12) cells and normal human bronchial epithelium B2B (BEAS-2B) cells, compared with the highly aggressive, metastatic mouse Lewis lung carcinoma (LLC1) cells, as well as H69 human SCLC cells (Fig. S1 E). Here, LMNB1 is linked to lung carcinoma.