Lamin disruption may simply affect cell migration and metastasis by increasing the plasticity of nuclear shape, thus facilitating changes in cell form that are required for penetrating restricted spaces, in particular during intravasation of cancer cells from primary tumors into the vasculature and extravasation into metastatic sites (Friedl et al., 2011; Denais et al., 2016). Here, LMNA is linked to cancer.