Increased caspase‐1 levels have also been detected in serum of ALS patients (Iłżecka et al, 2001), and analysis of postmortem spinal cord tissue showed increased NLRP3, ASC, caspase‐1, and IL‐18 expression levels, with spinal cord astrocytes identified as the main NLRP3 inflammasome‐expressing cell type (Johann et al, 2015). Here, NLRP3 is linked to amyotrophic lateral sclerosis.