At the genome level, GO analysis identified a large number of the 936 genes to be significantly enriched in smooth muscle cell functions and CAD-associated terms, including vasculogenesis, angiogenesis, cell adhesion, and proliferation in biological processes; myocardial infarction, cardiovascular diseases, and coronary artery calcification in GAD enrichment; ECM and cell adhesion in KEGG pathways (Fig. 6f, g, Additional file 1: Figure S5E, Additional file 3: Table S2, Additional file 4: Table S3). This evidence concerns the gene GAD1 and cardiovascular disorder.