STIM1 and B-cell chronic lymphocytic leukemia: Used alone GOK and RTX did not reduce in vitro B-CLL cell survival as compared to the controls, but in contrast the RTX + GOK combination significantly reduced cell viability in the STIM1PM high subgroup (50.4 ± 6.4% with IgG2a versus 23.0 ± 4.7% with RTX + GOK, P = 0.03), an effect which was not significant in the STIM1PM low subgroup (33.5 ± 6.5% with IgG2 versus 20.3 ± 4.7% with RTX + GOK).