First, specific blockade of Orai1 channels with S66 at 2.5 μM significantly reduced CE (P = 0.03), the anti-IgM Ca2+ response (P = 0.01), and TG SOCE (P = 0.05) but not TG ER Ca2+ release in CE+/IgM+ B-CLL cells compared to control conditions (Fig. 3a/b and data not shown). Here, CD40LG is linked to B-cell chronic lymphocytic leukemia.