STIM1 and B-cell chronic lymphocytic leukemia: Since glycosylation is required for STIM1 localization at the plasma membrane [24, 25], and given that the pool of STIM1 located in the plasma membrane (STIM1PM) regulates store-independent Ca2+ influx [26], this raises the possibility that STIM1PM controls CE and contributes to its enhancement in CE+ B-CLL cells.