CD40LG and B-cell chronic lymphocytic leukemia: Interestingly, by conducting a bivariate analysis of PFS on both CE and IgM Ca2+ mobilization, we further observed that CLL patients with disease progression were restricted to CE+/IgM+ (n = 11) and CE+/IgM- (n = 5) CLL patients but not to CE−/IgM+ (n = 4) and CE−/IgM- (n = 9) CLL patients (P = 0.006, Fig. 2b).