STIM1 and B-cell chronic lymphocytic leukemia: STIM1 deregulation in B-CLL cells needs further exploration as it may be related to defective transcriptional control by DNA methylation and/or microRNAs [31, 32], and/or is related to post-translational modifications such as glycosylation and/or phosphorylation known to affect STIM1 localization and properties [24, 33], as these processes are altered during CLL evolution [34].