In contrast, sera from IRIS291 tumor-bearing mice injected with IRIS-pep contained 0.25 ± 0.01 ng/ml, an ~ 69% decrease in the level of circulating IL-6 in these mice (p < 0.000001, Fig. 3c, upper left red), and sera from IRIS293 tumor-bearing mice injected with IRIS-pep contained 0.25 ± 0.03 ng/ml, an ~ 67% decrease in the level of circulating IL-6 in these mice (p = 0.0000001, Fig. 3c, upper right green). Here, IL6 is linked to neoplasm.