In contrast, sera from MDA-231/shIRIS tumor-bearing mice contained 0.33 ± 0.11 ng/ml, an ~ 65% decrease in the level of circulating IL-6 in these mice (p = 0.0001, Fig. 2c, upper left orange), and sera from MDA-468/shIRIS tumors-bearing mice contained 0.30 ± 0.12 ng/ml, an ~ 66% decrease in the level of circulating IL-6 in these mice (p = 0.0003, Fig. 2c, upper right green). The gene discussed is IL6; the disease is neoplasm.