IL6 and neoplasm: The results suggest that IL-6R is expressed primarily by the infiltrated MSCs—not IRISOE TNBC tumor cells—and that even in vivo, suppressing IRIS expression in IRISOE TNBC cells converts them into luminal A tumor cells, correlated with suppression in IL-6 secretion, and prevention in CD90+/IL-6R+ MSC recruitment into IRISOE tumors; especially the aggressiveness niche [12, 34] and their conversion into PGE2-secreting cells.