In contrast, in 4T1/shIris1 tumors (Fig. 4e7), we observed a significant reduction in CK5 expression in tumor cells (Fig. 4e8 and 9` arrowheads), a complete absence of the CD90+ cells (Fig. 4e10 and 11` arrowheads), and the IL-6R+ cells (Fig. 4e12). The gene discussed is KRT5; the disease is neoplasm.