Finally, the gene set “IL-6 plus PTGER2 plus PTGER4” once confirmed as a diagnostic tool for detection of IRISOE TNBC tumor cells could activate a treatment protocol directed at blocking the activity of these factors to interrupt IRISOE TNBC tumor cell/MSC-positive bi-directional feedback loop, which could lead to better patient outcomes. Here, PTGER2 is linked to neoplasm.