As hMICL and CD123 were all markers of LSC, highly and stably expressed in most of AML, Rough et al. reported that combining hMICL/CLL-1 and CD123 with CD45/CD34/CD117 can sensitively detect MRD which is comparable with a real-time quantitative polymerase chain reaction, irrespective of CD34+ status [39]. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.