Van et al. proposed to combine a toxic moiety to anti-CLL-1 antibody to induce killing effect [32], where two kinds of anti-CLL-1 antibody-drug conjugate with pyrrolobenzodiazepine (DCLL9718A) and isoquinolidinobenzodiazepine (CLT030), respectively, have shown powerful response to AML in animal models with no or little target off tumor toxicities [41–43]. The gene discussed is CLEC12A; the disease is acute myeloid leukemia.