Van et al. proposed to combine a toxic moiety to anti-CLL-1 antibody to induce killing effect [32], where two kinds of anti-CLL-1 antibody-drug conjugate with pyrrolobenzodiazepine (DCLL9718A) and isoquinolidinobenzodiazepine (CLT030), respectively, have shown powerful response to AML in animal models with no or little target off tumor toxicities [41–43]. This evidence concerns the gene CLEC12A and neoplasm.