CCN3 and chronic myelogenous leukemia, BCR-ABL1 positive: By analyzing the clinical samples collected from the different clinical staging of CML patients and also measuring the methylation levels following imatinib therapy, we further validated that the CCN3 remains hypermethylated in the patients following treatment with BCR-ABL1 tyrosine kinase inhibitor, imatinib; as well as in different clinical stages.