Gene expression analysis after depletion of SNHG15 revealed significant deregulation of multiple genes including CTGF, GADD45A, GADD45B, HAS2, LAMC3, NRAS, BAG3, ERBB3, MYC and CASP3. Most of these genes are known to play an important role in CRC tumor development and response to treatment. Here, ERBB3 is linked to colorectal carcinoma.