It has also been reported that, HOTAIR might accelerate neoplasm aggressiveness by upregulation of VEGF, MMP-9, and epithelial-mesenchymal transition (EMT)-related genes by decreasing the expression of E-cadherin while increasing the expression of β-catenin, Vimentin (VIM), Snail, and Twist [106]. Here, VIM is linked to neoplasm.