CDK2 and cancer: We demonstrated that the anti-cancer effect of MF does not require the presence of progesterone receptors [9], involves cell cycle arrest at the G1 phase of the cell cycle associated with the inhibition of cyclin-dependent kinase Cdk2 [10, 11], and triggers cellular stress and autophagy, making it useful in combination therapies with proteasome inhibitors and autophagy blockers [12].