Comparing the overall seroprevalence of anti-DENV IgM (11.5%) with the overall incidence of reported dengue patients (3.1%) in West Central District, North District, and East District, we therefore estimated that 1 out of 3.7 DENV infections was confirmed and reported to health authority in Taiwan in the 2015 epidemic, which was very different from Singapore where it was estimated that 1 out of 23 and 35 of DENV infections were notified in 2004 and 2007, respectively [18, 19]. Here, CD40LG is linked to infection.