VEGFA and age-related macular degeneration: Although the natural progression and the visual prognosis of ICNV are more favorable than for CNV attributable to age-related macular degeneration (AMD), and majorities of patients with ICNV have good response to anti-vascular endothelial growth factor (VEGF) therapy, some of these patients nonetheless have persistent CNV, and even decreased vision, and need repeated anti-VEGF therapy [3–6].