FGFR2 and colorectal cancer: NCI-H716 colorectal cancer cell line was included as a control, harboring an amplified full length FGFR2 kinase, whose hyper-activation is due to gene amplification and not to the presence of a concomitant fusion at the FGFR2 C-terminal with COL14A1 gene, conserving an intact kinase sequence [32].