TRPM3 and myalgic encephalomeyelitis/chronic fatigue syndrome: With the use of PregS and nifedipine as reversible activators of TRPM3 channels as well as ononetin as a potent blocker of PregS- and nifedipine- evoked Ca2+-influx and ionic currents, we aim to validate the previous research findings describing an impaired TRPM3 activity in a new cohort of CFS/ME patients using whole cell patch-clamp techniques.