As PregS and nifedipine act on TRPM3 via separate binding sites (Drews et al., 2014), since co-application of PregS and nifedipine caused a larger activation of TRPM3 than applying these compounds alone, a drugs combination approach may be considered for CFS/ME therapy. The gene discussed is TRPM3; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.