Chronic kidney disease (CKD)-mineral bone disorder (MBD) develops as a systemic disorder of mineral and bone metabolism, including laboratory abnormalities such as parathyroid hormone (PTH), vitamin D, calcium, phosphate, fibroblast growth factor 23 (FGF-23), bone abnormalities, and vascular calcification [1]. The gene discussed is FGF23; the disease is Marchiafava-Bignami disease.