But the presence of chronic MS pain was independently significantly associated with all-cause mortality (HR, 2.912, 95% CI, 1.004–8.444; p = .049) after adjustment of age, gender, co-morbidity of diabetes, hypertension, baseline eGFR, serum hemoglobin, albumin, hs-CRP, calcium, phosphate, Ca × P, and proteinuria. The gene discussed is ALB; the disease is Hypertension.