The 99th centile of high-sensitivity cardiac troponin T (cTnT) and troponin I (cTnI), derived from a normal reference population, is used to detect myocardial necrosis as part of a diagnosis of myocardial infarction.1,2 However, low-grade elevations in troponin in the general population, well below the diagnostic threshold, are also associated with future cardiovascular disease (CVD) events and may have a role in screening the general population for CVD risk.3,4. The gene discussed is TNNI3; the disease is myocardial infarction.