These transgenic mice showed reduced growth of Lewis lung carcinoma (LLC) cell and B16 melanoma cell transplants, indicating that CXCL14, which was first identified as a suppressor of tumor progression when overexpressed in HNSCC cells also suppressed adenocarcinoma derived from LLC cells and melanoma cells [29]. This evidence concerns the gene CXCL14 and head and neck squamous cell carcinoma.