We found that the CXCL14 promoter region in YCU-H891 cells was hypermethylated and that demethylation of the promoter by treatment with 5-aza-2′-deoxycytidine (DAC) restored CXCL14 mRNA expression and in vivo cetuximab-mediated tumor growth suppression. This evidence concerns the gene CXCL14 and neoplasm.