Cystic fibrosis (CF) is the most common lethal monogenic autosomal recessive disease among the Caucasian population, and it is caused by dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which normally functions as a chloride/bicarbonate channel at the apical plasma membrane (PM) of epithelial cells [1]. This evidence concerns the gene CFTR and cystic fibrosis.