Fujimoto et al. [43] proposed heme oxygenase-1 (HO-1) as a possible serum biomarker to monitor transformation and fluctuations of the 8-hydroxy-2-deoxy guanosine (8-OHdG), HO-1, total antioxidant capacity (TAC) and heme iron concentrations to be characteristic of each stage of tumor growth, mainly the initiation and progression stages. Here, HMOX1 is linked to neoplasm.