Moreover, the antioxidant effect of PG in Parkinson’s disease model was associated with the increased expression of nuclear factor erythroid 2-related factor (Nrf2), and the activation of Nrf2-mediated antioxidant systems [22]; similarly, Nrf2 was found to be involved in the inhibition of osteoclastogenesis by this substance [23]. Here, NFE2L2 is linked to Parkinson disease.