CTF1 and obesity due to melanocortin 4 receptor deficiency: In the present analysis, we examined the mRNA expression of CT-1 in subcutaneous AT and its association with clinical variables in a population of 22 healthy women with obesity (30 ± 6 years of age; 32.4 ± 2.5 kg/m2), as well as a cohort of 15 lean men who were overfed by 40% more than their baseline energy requirements for 8-weeks (25 ± 4 years of age; BMI 24.7 ± 2.1 kg/m2).