In postmenopausal women with T2DM, 1-year dietary intervention with flavonoid-enriched chocolate (850 mg flavan-3-ols/d) combined with isoflavones (100 mg/d) resulted in significant improvements in insulin sensitivity and reduced insulin concentrations, demonstrating additional benefits of a flavan-3-ols/isoflavone mixture to standard drug therapy on various cardio-metabolic risk endpoints [109]. This evidence concerns the gene INS and type 2 diabetes mellitus.