Paxillin is a scaffold protein acting by recruiting signaling proteins to the plasma membrane and when it is phosphorylated by FAK or Src, additional binding sites for adaptor proteins are generated; the inhibition of its phosphorylation is therefore relevant to reduce the activation of oncogenic pathways with key roles in cancer cell proliferation and chemoresistance such as Akt and ERK1/2. Here, PTK2 is linked to cancer.