Furthermore, South Asian men exhibited impaired CVD and T2D risk markers compared with white European men comprising: (1) elevated fasting concentrations of insulin, leptin, CRP, IL-6 and TAG and a higher TC/HDL-C ratio; (2) lower fasting concentrations of HDL-C; and (3) higher glucose and insulin concentrations during the OGTT. This evidence concerns the gene LEP and type 2 diabetes mellitus.